Dianne Wiest was 59 in Synecdoche, New York when she played the character 'Ellen Bascomb / Millicent Weems'.
That was over 16 years ago in 2008.
Today she is 76, and has starred in 54 movies in total, 14 of those since Synecdoche, New York was released.
In Synecdoche, New York, I think Dianne Wiest looks: