That was over 16 years ago in 2005.
Today she is 62, and has starred in 64 movies in total, 40 since The 40 Year Old Virgin was released.
In The 40 Year Old Virgin, I think Catherine Keener looks:
The 40 Year Old Virgin scores 6.2 out of 10 on The Movie Database.
Catherine Keener's first acting role was as 'Cheryl' in Survival Quest, released in 1989 when she was 30.