Alex Borstein was 29 in A Very Special Family Guy Freakin' Christmas when she played the character 'Lois Griffin / Female Hipster / Julie / Grandma (voice)'.
That was over 21 years ago in 2001.
This was her first recorded movie acting credit (although may not technically be her first actual acting role).
Today she is 52, and has starred in 34 movies in total, 33 of those since A Very Special Family Guy Freakin' Christmas was released.
In A Very Special Family Guy Freakin' Christmas, I think Alex Borstein looks: