That was over 62 years ago in 1959.
In 1986 he died aged 82, starring in 92 films in his career, 17 since North by Northwest was released.
In North by Northwest, I think Cary Grant looks:
North by Northwest scores 7.9 out of 10 on The Movie Database.
Cary Grant's first acting role was as 'Lt. Jaeckel' in Devil and the Deep, released in 1932 when he was 28.