Tress MacNeille was 55 in The Simpsons Movie when she played the character 'Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)'.
That was over 17 years ago in 2007.
Today she is 72, and has starred in 138 movies in total, 36 of those since The Simpsons Movie was released.
In The Simpsons Movie, I think Tress MacNeille looks: