That was over 18 years ago in 2004.
Today she is 46, and has starred in 68 movies in total, 20 since 50 First Dates was released.
In 50 First Dates, I think Drew Barrymore looks:
50 First Dates scores 6.6 out of 10 on The Movie Database.
Drew Barrymore's first acting role was as 'Margaret Jessup' in Altered States, released in 1980 when she was 5.