Catherine O'Hara was 23 in Witch's Night Out when she played the character 'Malicious'.
That was over 46 years ago in 1978.
This was her first recorded movie acting credit (although may not technically be her first actual acting role).
Today she is 70, and has starred in 73 movies in total, 70 of those since Witch's Night Out was released.
In Witch's Night Out, I think Catherine O'Hara looks: