That was over 3 years ago in 2018.
Today he is 42, and has starred in 48 movies in total, 6 since Annihilation was released.
In Annihilation, I think Oscar Isaac looks:
Annihilation scores 6.3 out of 10 on The Movie Database.
Oscar Isaac's first acting role was as 'Pool Boy' in Illtown, released in 1998 when he was 18.